Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/51350

TítuloEngineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration
Autor(es)Pesqueira, Tamagno
Almeida, Raquel Carvalho Ferreira Costa
Mithieux, Suzanne M.
Babo, Pedro Miguel Sousa
Franco, Albina Ribeiro
Mendes, Bárbara B.
Domingues, Rui Miguel Andrade
Freitas, Paulo
Reis, R. L.
Gomes, Manuela E.
Weiss, Anthony S.
Palavras-chaveMagnetic field
Magnetic nanoparticles
Spongy-like hydrogel
Tropoelastin
Data26-Jan-2018
EditoraRoyal Society of Chemistry
RevistaJournal of Materials Chemistry B
CitaçãoPesqueira T., Costa-Almeida R., Mithieux S. M., Babo P. S., Franco A. R., Mendes B. B., Domingues R. M. A., Freitas P., Reis R. L., Gomes M. E., Weiss A. S. Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration, Journal Of Materials Chemistry B, doi:10.1039/C7TB02035J, 2018
Resumo(s)Magnetic biomaterials are a key focus in medical research. Tropoelastin is the soluble precursor of elastin and is a critical component of tissues requiring elasticity as part of their physiological function. By utilising the versatility of tropoelastin and the ability to tailor its properties, we developed a novel magnetic spongy-like hydrogel based on tropoelastin doped with magnetic properties by in situ precipitation method. The presence of magnetic nanoparticles altered the secondary structure of tropoelastin. Bioengineered tropoelastin-based magnetic spongy-like hydrogels displayed a homogenous distribution of magnetic nanoparticles throughout the tropoelastin network and quick magnetic responsiveness to an applied external magnetic field. Morphologically, in the presence of magnetic nanoparticles, hydrated tropoelastin spongy-like hydrogels showed apparently smaller pore sizes and less swelling. Furthermore, in vitro biological studies using human tendon-derived cells revealed that magnetically responsive tropoelastin spongy-like hydrogels supported cell viability and enabled cell adhesion, spreading and migration into the interior of the spongy-like hydrogel up to two weeks. The bioengineered tropoelastin-based magnetic spongy-like hydrogel represents a novel class of hybrid biomaterial that can serve as a platform for soft tissue regeneration.
Tipoarticle
URIhttp://hdl.handle.net/1822/51350
DOI10.1039/C7TB02035J
ISSN2050-750X
e-ISSN2050-7518
Versão da editorahttp://pubs.rsc.org/en/content/articlelanding/2018/tb/c7tb02035j#!divAbstract
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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