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|Title:||Silk fibroin/hydroxyapatite composites for bone tissue engineering|
Shokrgozar, Mohammad Ali
Kundu, Subhas C
Reis, R. L.
Kaplan, David L.
Bone tissue engineering
|Citation:||Farokhi M., Mottaghitalab F., Samani S., Shokrgozar M. A., Kundu S. C., Reis R. L., Fattahi Y., Kaplan D. L. Silk fibroin/hydroxyapatite composites for bone tissue engineering, Biotechnology Advances, Vol. 36, pp. 68-91, doi:10.1016/j.biotechadv.2017.10.001, 2017|
|Abstract(s):||Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity has limited applicationsÂ for SF in the orthopedic arena unless suitably functionalized. Hydroxyapatite (HAp) is a well-establishedÂ bioceramic with biocompatibility and appropriate for constructing orthopedic and dental substitutes.Â However, HAp ceramics tend to be brittle which can restrict applications in the repair of load-bearing tissuesÂ such as bones. Therefore, blending SF and HAp combines the useful properties of both materials as bone constructs for tissue engineering, the subject of this review.|
|Access:||Restricted access (Author)|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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|19328-Farokhi M et al 2018 Biotech. Advances 36, 68-91 Silk fibroinhydroxyapatite composites for bone tissue engineering.pdf|
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