Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51330

TitleSilk fibroin/hydroxyapatite composites for bone tissue engineering
Author(s)Farokhi, Mehdi
Mottaghitalab, Fatemeh
Samani, Saeed
Shokrgozar, Mohammad Ali
Kundu, Subhas C
Reis, R. L.
Fattahi, Yousef
Kaplan, David L.
KeywordsSilk Fibroin
Hydroxyapatite
Scaffold
Bone tissue engineering
Issue date2018
PublisherElsevier
JournalBiotechnology Advances
CitationFarokhi M., Mottaghitalab F., Samani S., Shokrgozar M. A., Kundu S. C., Reis R. L., Fattahi Y., Kaplan D. L. Silk fibroin/hydroxyapatite composites for bone tissue engineering, Biotechnology Advances, Vol. 36, pp. 68-91, doi:10.1016/j.biotechadv.2017.10.001, 2017
Abstract(s)Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity has limited applications for SF in the orthopedic arena unless suitably functionalized. Hydroxyapatite (HAp) is a well-established bioceramic with biocompatibility and appropriate for constructing orthopedic and dental substitutes. However, HAp ceramics tend to be brittle which can restrict applications in the repair of load-bearing tissues such as bones. Therefore, blending SF and HAp combines the useful properties of both materials as bone constructs for tissue engineering, the subject of this review.
TypeArticle
URIhttp://hdl.handle.net/1822/51330
DOI10.1016/j.biotechadv.2017.10.001
ISSN0734-9750
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals


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