Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/51321

TítuloEmerging tumor spheroids technologies for 3D in vitro cancer modeling
Autor(es)Rodrigues, Tânia
Kundu, Banani
Silva-Correia, Joana
Kundu, Subhas C
Oliveira, J. M.
Reis, R. L.
Correlo, V. M.
3D Tumor Models
Multicellular Tumor Spheroids
RevistaPharmacology & Therapeutics
CitaçãoRodrigues T., Kundu B., Silva-Correia J., Kundu S. C., Oliveira J. M., Reis R. L., Correlo V. M. Emerging tumor spheroids technologies for 3D in vitro cancer modeling, Pharmacology & Therapeutics, doi:10.1016/j.pharmthera.2017.10.018, 2018.
Resumo(s)Cancer is a leading cause of mortality and morbidity worldwide. Around 90% of deaths are caused by metastasis and just 10% by primary tumor. The advancement of treatment approaches is not at the same rhythm of the disease; making cancer a focal target of biomedical research. To enhance the understanding and promts the therapeutic delivery; concepts of tissue engineering are applied in the development of in vitro models that can bridge between 2D cell culture and animal models, mimicking tissue microenvironment. Tumor spheroid represents highly suitable 3D organoid-like framework elucidiating the intra and inter cellular signaling of cancer, like that formed in physiological niche. However, spheroids are of limited value in studying critical biological phenomenon such as tumor-stroma interactons involving extra cellular matrix or immune system. Therefore, a compelling need of tailoring spheroid technologies with physiologically relevant biomaterials or in silico models, is ever emerging. The diagnostic and prognostic role of spheroids rearrangements within biomaterials or microfluidic channel is indicative of patient management; particularly for the decision of targated therapy. Fragmented information on available in vitro spheroid models and lack of critical analysis on transformation aspects of these strategies; pushes the urge to comprehensively overview the recent technological advancements (e.g. bioprinting, micro-fluidic technologies or use of biomaterials to attain the third dimension) in the shed of tranlationable cancer research. In present article, relationships between current models and their possible exploitation in clinical success is explored with the highlight of existing challenges in defining therapeutic targets and screening of drug efficacy.
Descrição"Article in Press, Available online 31 October 2017" ; "S0163-7258(17)30268-1"
Versão da editorahttps://doi.org/10.1016/j.pharmthera.2017.10.018
Arbitragem científicayes
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
19251-T. Rodrigues et al.pdf739,5 kBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis