Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51208

TitleRed blood cells radial dispersion in blood flowing through microchannels: the role of temperature
Author(s)Pinho, Diana
Rodrigues, Raquel O.
Faustino, Vera
Yaginuma, T.
Exposto, José
Lima, Rui Alberto Madeira Macedo
KeywordsDiffusion
Erythrocytes
Hematocrit
Hemodynamics
Hemorheology
Humans
Microfluidics
Microscopy
Microvessels
Temperature
Radial dispersion
Blood flow
Biomicrofluidics
Microcirculation
Red blood cells
Confocal micro-PTV
Issue date2016
PublisherElsevier
JournalJournal of Biomechanics
Abstract(s)The behavior of suspensions of individual blood cells, such as red blood cells (RBCs), flowing through microvessels and microfluidic systems depend strongly on the hematocrit (Hct), microvessel topology and cell properties. Although it is well known that blood rheological properties are temperature dependent, to the best of our knowledge no work has studied the role of the temperature on the RBCs dispersion. A powerful way to investigate this latter effect is through a high-speed video microscopy system, which provides detailed flow measurements of each individual RBC. Hence, the effect of temperature on the RBCs dispersion flowing through a 100μm glass capillary was examined by means of a confocal micro-PTV system. Hundreds of labeled RBCs were tracked at moderate Hct (12%) and at four different temperatures, i.e., 25°C, 32°C, 37°C and 42°C. The results yielded an enhancement of the RBCs diffusion as the temperature increases. Hence, our findings show that RBCs radial dispersion is temperature dependent and as a result the temperature should not be ignored in future blood flow studies. We believe that this finding is important for a better understanding of blood mass transport mechanisms under both physiological and pathological conditions.
TypeArticle
URIhttp://hdl.handle.net/1822/51208
DOI10.1016/j.jbiomech.2015.11.037
ISSN0021-9290
e-ISSN1873-2380
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:DEM - Artigos em revistas de circulação internacional com arbitragem científica

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