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TitleLow cost microfluidic device for partial cell separation: micromilling approach
Author(s)Lopes, Raquel
Rodrigues, Raquel O.
Pinho, Diana
Garcia, Valdemar
Schütte, Helmut
Lima, Rui Alberto Madeira Macedo
Gassmann, Stefan
Microfluidic device
Nonlithographic technique
Red blood cells
Cell-free layer
Issue date2015
JournalProceedings of the IEEE International Conference on Industrial Technology
Abstract(s)Several studies have already demonstrated that it is possible to perform blood flow studies in microfluidic systems fabricated by using low-cost techniques. However, most of these techniques do not produce microchannels smaller than 100 microns and as a result they have several limitations related to blood cell separation. Recently, manufacturers have been able to produce milling tools smaller than 100 microns, which consequently have promoted the ability of micromilling machines to fabricate microfluidic devices able to perform separation of red blood cells (RBCs) from plasma. In this work, we show the ability of a micromilling machine to manufacture microchannels with dimensions down to 30 microns. Additionally, we show for the first time the ability of the proposed microfluidic device to enhance the cell-free layer close to the walls, leading to perform partial separation of RBCs from plasma.
TypeConference paper
AccessOpen access
Appears in Collections:DEM - Publicações em actas de encontros científicos / Papers in conference proceedings

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