Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51097

TitleBlood flow visualization and measurements in microfluidic devices fabricated by a micromilling technique
Author(s)Singhal, Jaron
Pinho, Diana
Lopes, Raquel
Sousa, Patricia C.
Garcia, Valdemar
Schütte, Helmut
Lima, Rui Alberto Madeira Macedo
Gassmann, Stefan
KeywordsBiomedical applications
Blood cells
Cell-free layer
Cells separation
Micromilling
Microfluidic devices
Issue date2015
PublisherBentham Science Publishers
JournalMicro and Nanosystems
Abstract(s)The most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 m and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this work, we show the ability of a micromilling machine to manufacture microchannels down to 30 m and also the ability of a microfluidic device to perform partial separation of red blood cells from plasma. Flow visualization and measurements were performed by using a high-speed video microscopy system. Advantages and limitations of the micromilling fabrication process are also presented.
TypeArticle
URIhttp://hdl.handle.net/1822/51097
DOI10.2174/1876402908666160106000332
ISSN1876-4029
e-ISSN1876-4037
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DEM - Artigos em revistas de circulação internacional com arbitragem científica

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