Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50698| Título: | SHANK proteins: roles at the synapse and in autism spectrum disorder |
| Autor(es): | Monteiro, Patrícia Feng, Guoping |
| Data: | 2017 |
| Editora: | Nature Publishing Group |
| Revista: | Nature Reviews Neuroscience |
| Citação: | Monteiro, P., & Feng, G. (2017, February 9). SHANK proteins: roles at the synapse and in autism spectrum disorder. Nature Reviews Neuroscience. Springer Science and Business Media LLC. http://doi.org/10.1038/nrn.2016.183 |
| Resumo(s): | Several large-scale genomic studies have supported an association between cases of autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat domains protein 1 (SHANK1), SHANK2 and SHANK3, which encode a family of postsynaptic scaffolding proteins that are present at glutamatergic synapses in the CNS. An evaluation of human genetic data, as well as of in vitro and in vivo animal model data, may allow us to understand how disruption of SHANK scaffolding proteins affects the structure and function of neural circuits and alters behaviour |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/50698 |
| DOI: | 10.1038/nrn.2016.183 |
| ISSN: | 1471-0048 |
| Versão da editora: | https://www.nature.com/articles/nrn.2016.183 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| monteiro, feng 2017.pdf | 462,78 kB | Adobe PDF | Ver/Abrir |
