Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50604

TitlePrediction of adverse pregnancy outcomes by extreme values of first trimester screening markers
Author(s)Gomes, Marina S.
Carlos-Alves, Mariana
Trocado, Vera
Arteiro, Diana
Pinheiro, Paula
KeywordsAbruptio placentae
Fetal growth
Human chorionic-gonadotrophin beta-subunit
Nuchal translucency
Pregnancy-associated plasma protein-A
Preeclampsia
Issue date24-May-2017
PublisherSAGE Publications
JournalObstetric Medicine
CitationGomes, M. S., Carlos-Alves, M., Trocado, V., Arteiro, D., & Pinheiro, P. (2017). Prediction of adverse pregnancy outcomes by extreme values of first trimester screening markers. Obstetric medicine, 10(3), 132-137
Abstract(s)Background To determine the association between extreme values of first trimester markers and adverse pregnancy outcomes. Methods A retrospective cohort study of 916 women who underwent first-trimester combined screening during 2015 was performed. Extreme values of NT, pregnancy-associated plasma protein-A (PAPP-A) and free -hCG, and their association with adverse pregnancy outcomes were analyzed. Results Low PAPP-A (<10th percentile) was associated with an increased risk for preeclampsia (adjusted odds ratio (AOR) 4.13), fetal growth restriction (AOR 3.94) and abruptio placentae (AOR 52.63). Abnormally low or high free -hCG, high PAPP-A or increased NT was not associated with an increased risk for adverse outcomes. Discussion PAPP-A <10th percentile could be associated with an increased risk for adverse outcomes. However, the majority of patients with these events do not have abnormal PAPP-A and few patients with PAPP-A <10th percentile will have an adverse outcome.
TypeArticle
URIhttp://hdl.handle.net/1822/50604
DOI10.1177/1753495X17704799
ISSN1753-495X
e-ISSN1753-4968
Publisher versionhttp://journals.sagepub.com/doi/10.1177/1753495X17704799
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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