Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/50603

TítuloBrain interference: Revisiting the role of IFNγ in the central nervous system
Autor(es)Monteiro, Susana Isabel Gonçalves
Roque, Susana
Marques, Fernanda
Correia-Neves, M
Cerqueira, João José
Palavras-chaveIFNγ
Neuroimmunology
Neuroinflammation
Central nervous system
Cytokine
IFN gamma
Data1-Set-2017
EditoraElsevier
RevistaProgress in Neurobiology
CitaçãoMonteiro, S., Roque, S., Marques, F., Correia-Neves, M., & Cerqueira, J. J. (2017). Brain interference: Revisiting the role of IFNγ in the central nervous system. Progress in neurobiology, 156, 149-163
Resumo(s)Interferon gamma (IFN-gamma) is a pro-inflammatory cytokine, first described as a secreted molecule capable of interfering with viral replication. Since then, numerous other important actions in the context of the immune response to invading pathogens (including those invading the brain) have been ascribed to this pleiotropic cytokine. Nevertheless, the precise role of IFN gamma in neuropsychiatric and neurodegenerative disorders, and its possible contribution to the regulation of normal brain function, remains enigmatic. This review integrates and considers current knowledge about IFN gamma actions with accumulating evidence of its importance on neurocytogenesis, synaptic plasticity and neurodegeneration within the framework of brain health and disease.
Tipoarticle
URIhttp://hdl.handle.net/1822/50603
DOI10.1016/j.pneurobio.2017.05.003
ISSN0301-0082
e-ISSN1873-5118
Versão da editorahttps://www.sciencedirect.com/science/article/pii/S0301008216300910
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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