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https://hdl.handle.net/1822/50603| Título: | Brain interference: Revisiting the role of IFNγ in the central nervous system |
| Autor(es): | Monteiro, Susana Isabel Gonçalves Roque, Susana Marques, Fernanda Correia-Neves, M Cerqueira, João José |
| Palavras-chave: | IFNγ Neuroimmunology Neuroinflammation Central nervous system Cytokine IFN gamma |
| Data: | 1-Set-2017 |
| Editora: | Elsevier |
| Revista: | Progress in Neurobiology |
| Citação: | Monteiro, S., Roque, S., Marques, F., Correia-Neves, M., & Cerqueira, J. J. (2017). Brain interference: Revisiting the role of IFNγ in the central nervous system. Progress in neurobiology, 156, 149-163 |
| Resumo(s): | Interferon gamma (IFN-gamma) is a pro-inflammatory cytokine, first described as a secreted molecule capable of interfering with viral replication. Since then, numerous other important actions in the context of the immune response to invading pathogens (including those invading the brain) have been ascribed to this pleiotropic cytokine. Nevertheless, the precise role of IFN gamma in neuropsychiatric and neurodegenerative disorders, and its possible contribution to the regulation of normal brain function, remains enigmatic. This review integrates and considers current knowledge about IFN gamma actions with accumulating evidence of its importance on neurocytogenesis, synaptic plasticity and neurodegeneration within the framework of brain health and disease. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/50603 |
| DOI: | 10.1016/j.pneurobio.2017.05.003 |
| ISSN: | 0301-0082 |
| e-ISSN: | 1873-5118 |
| Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0301008216300910 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| untitled.pdf | 1,86 MB | Adobe PDF | Ver/Abrir |
