Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50582

TitleBiomechanical considerations in the pathogenesis of osteoarthritis of the knee
Author(s)Heijink, Andras
Gomoll, Andreas H.
Madry, Henning
Drobnič, Matej
Filardo, Giuseppe
Espregueira-Mendes, João
Van Dijk, C. Niek
KeywordsAging
Animals
Anterior Cruciate Ligament Injuries
Biomechanical Phenomena
Cartilage, Articular
Chondrocytes
Comorbidity
Homeostasis
Humans
Joint Instability
Knee Joint
Osteoarthritis, Knee
Oxidative Stress
Rupture
Malalignment
Meniscus
Osteochondral defects
Joint instability
Pathology
Etiology
Cartilage
Issue dateMar-2012
PublisherSpringer
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Abstract(s)Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an unfavorable biomechanical environment at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity. Level of evidence IV.
TypeArticle
URIhttp://hdl.handle.net/1822/50582
DOI10.1007/s00167-011-1818-0
ISSN0942-2056
e-ISSN1433-7347
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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