Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50483

TitleEvaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research
Author(s)Sousa, Cristina P.
Lopez-Peña, Mónica
Guzon, Fernando M.
Abreu, Humberto V. de
Luís, Maurino R.
Viegas, Carlos A.
Camassa, José A.
Azevedo, Jorge T.
Cabrita, A. S.
Reis, R. L.
Gomes, Manuela E.
Dias, Isabel R.
KeywordsBone turnover markers
Critical size defect
Delayed union
Fracture healing process
Non-union
Sheep
Issue dateAug-2017
PublisherElsevier
JournalInjury-international Journal Of The Care Of The Injured
CitationSousa C. P., Lopez-Peña M., Gúzon F. M., De Abreuc H. V., Luís M. R., Viegas C. A., Camassa J., De Azevedo J. T., Cabrita A. S., Reis R. L., Gomes M. E., Dias I. R. Evaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research, Injury-international Journal Of The Care Of The Injured, doi:10.1016/j.injury.2017.05.025, 2017
Abstract(s)Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers SOH namely the total alkaline phosphatase (ALP) and its bone-specific isoform (BALP), serum concentration of intact osteocalcin (OC), N-terminal propeptide type III procollagen (PIIINP) and of bone resorption markers â  namely tartrate resistant acid phosphatase (TRAP) and deoxypyridinoline crosslink (DPD) during the first stages of a normal fracture healing process and of a segmental critical size defect (CSD), which progresses to a non-union process. Thirty healthy female sheep (Portuguese Churra-da-Terra- Quente breed), approximately 4-years-old, were enrolled in this study. Jugular venous blood samples were collected pre-operatively and at 1, 2, 3, 4, 6, 8, 10 and 12 post-operative weeks. The animals of the CSD group showed significant lower serum levels of BALP, OC and significant higher serum PIIINP levels at early stages of the fracture healing process, compared with animals that progressed in a normal fracture healing process. Serum BALP, OC and PIIINP levels could be useful as non-invasive auxiliary tools with other complementary methods for predicting the outcome of traumatic bone fractures.
TypeArticle
URIhttp://hdl.handle.net/1822/50483
DOI10.1016/j.injury.2017.05.025
ISSN0020-1383
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0020138317303509
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
19163-CristinaSousa_Injury2017.pdf781,12 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID