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TitleEvaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research
Author(s)Sousa, Cristina P.
Lopez-Peña, Mónica
Guzon, Fernando M.
Abreu, Humberto V. de
Luís, Maurino R.
Viegas, Carlos A.
Camassa, José A.
Azevedo, Jorge T.
Cabrita, A. S.
Reis, R. L.
Gomes, Manuela E.
Dias, Isabel R.
KeywordsBone turnover markers
Critical size defect
Delayed union
Fracture healing process
Issue dateAug-2017
JournalInjury-international Journal Of The Care Of The Injured
CitationSousa C. P., Lopez-Peña M., Gúzon F. M., De Abreuc H. V., Luís M. R., Viegas C. A., Camassa J., De Azevedo J. T., Cabrita A. S., Reis R. L., Gomes M. E., Dias I. R. Evaluation of bone turnover markers and serum minerals variations for predicting fracture healing versus non-union processes in adult sheep as a model for orthopedic research, Injury-international Journal Of The Care Of The Injured, doi:10.1016/j.injury.2017.05.025, 2017
Abstract(s)Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers SOH namely the total alkaline phosphatase (ALP) and its bone-specific isoform (BALP), serum concentration of intact osteocalcin (OC), N-terminal propeptide type III procollagen (PIIINP) and of bone resorption markers â  namely tartrate resistant acid phosphatase (TRAP) and deoxypyridinoline crosslink (DPD) during the first stages of a normal fracture healing process and of a segmental critical size defect (CSD), which progresses to a non-union process. Thirty healthy female sheep (Portuguese Churra-da-Terra- Quente breed), approximately 4-years-old, were enrolled in this study. Jugular venous blood samples were collected pre-operatively and at 1, 2, 3, 4, 6, 8, 10 and 12 post-operative weeks. The animals of the CSD group showed significant lower serum levels of BALP, OC and significant higher serum PIIINP levels at early stages of the fracture healing process, compared with animals that progressed in a normal fracture healing process. Serum BALP, OC and PIIINP levels could be useful as non-invasive auxiliary tools with other complementary methods for predicting the outcome of traumatic bone fractures.
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AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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