Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50481

TitleSynthesis of new 9-(4´-RO-phenyl)-6-cyanopurine derivatives
Author(s)Rocha, Ashly
Proença, M. Fernanda R. P.
Carvalho, M. Alice
Issue date2015
Abstract(s)Cancer remains to be one of the leading causes of death worldwide of which the scientific community continuously struggles to combat on a daily basis [1]. In developed countries, colorectal cancer is one of the most frequent types of cancer where busy and stressful lifestyles contribute to diets rich in unhealthy fats which can be a preliminary cause of this cancer [2]. Unfortunately, there is not a concrete cure for this cancer and not all patients respond equally to the administered drugs [3]. Some even develop tumor resistance upon the intake of their therapeutic drugs due to the tumors’ different genetic profiles [3]. The ineffective treatment in many patients causes thousands of annual casualties which stimulated further research in prospect of novel anticancer drugs [1]. Recently, in our research group, the pyrimido[5,4-d]pyrimidines of general structure 1 (Figure 1) were identified as a new class of heterocyclic compounds active against HCT116 (p-53wt) colon cancer cells. The biological results showed that the activity depends on the substituents R and R1 that decorate the heterocycle. The synthetic strategy developed in our research group to generate the pyrimidopyrimidine ring has the 9-substitutedpurines as crucial intermediates [5, 6, 7], that are not available commercially. Herein, we describe the synthesis of new 9-substitutedpurine derivatives that will be used as starting reagents to synthesize new pyrimido[5,4-d]pyrimidines.
TypeAbstract
URIhttp://hdl.handle.net/1822/50481
Peer-Reviewedno
AccessRestricted access (Author)
Appears in Collections:CDQuim - Comunicações e Proceedings

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