Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50477

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dc.contributor.authorRocha, Ashlypor
dc.contributor.authorFernandes, Joanapor
dc.contributor.authorLima, Cristóvão Fernando Macedopor
dc.contributor.authorProença, M. Fernanda R. P.por
dc.contributor.authorPereira-Wilson, Cristinapor
dc.contributor.authorCarvalho, M. Alicepor
dc.date.accessioned2018-02-15T10:06:23Z-
dc.date.issued2015-
dc.identifier.urihttp://hdl.handle.net/1822/50477-
dc.description.abstract[Excerpt] Colorectal cancer (CRC) is amongst the most common types of cancer in developed countries due to common sedentary lifestyles and unhealthy diets.1 Chemotherapy has a key role in combating this disease but the current approved drugs are not effective for all patients due to the tumours’ different genetic profiles. The p53 is frequently mutated in several types of cancer causing treatment resistance.2,3,4 Other genetic alterations frequently present in CRC include KRas or BRaf activating mutations which increase proliferative behavior. These mutations are known to be responsible for resistance to targeted therapy with growth factor receptor inhibitor mediated agents. Therefore, the need to increase treatment efficacy and to overcome resistance continues to stimulate anticancer drug discovery. [...]por
dc.description.sponsorshipWe acknowledge University of Minho, FCT: projects nºF-COMP-01-0124-FEDER-022716 (ref. FCT PEst/QUI/UI0686/2011) FEDER-COMPETE, National NMR Network (Bruker 400 Avance III), research grant Pest-C/BIA/UI4050/2011, co-funded by the program COMPETE from QREN with co-participation from the European Community fund FEDER and PhD grant awarded to A. Rocha SFRH/BD/85937/2012 for financial support.por
dc.language.isoengpor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F85937%2F2012/PTpor
dc.rightsclosedAccesspor
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/por
dc.titleNew pyrimido[5,4-d]pyrimidines with enhanced anticancer activity on colorectal cancer cells: synthesis, SAR study and mechanism of actionpor
dc.typeoralPresentationpor
dc.peerreviewednopor
oaire.citationConferenceDate01 - 03 Dez. 2015por
sdum.event.title11º Encontro Nacional de Química Orgânica/4º Encontro Nacional de Química Terapêuticapor
sdum.event.typeconferencepor
oaire.citationConferencePlacePorto, Portugalpor
dc.subject.fosCiências Naturais::Ciências Químicaspor
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersionpor
Appears in Collections:CDQuim - Comunicações e Proceedings

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