Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50465

TitleSilk fibroin-magnetic hybrid composite electrospun fibers for tissue engineering applications
Author(s)Brito-Pereira, R.
Correia, D. M.
Ribeiro, Clarisse
Francesko, A.
Etxebarria, I.
Pérez-Ãlvarez, L.
Vilas, J. L.
Martins, Pedro Libânio Abreu
Lanceros-Méndez, S.
KeywordsSilk-fibroin
Nanoparticles
Electrospinning
Tissue engineering
Issue date15-May-2018
PublisherElsevier
JournalComposites Part B: Engineering
CitationBrito-Pereira, R.; Correia, D. M.; Ribeiro, Clarisse; Francesko, A.; Etxebarria, I.; Pérez-Ã lvarez, L.; Vilas, J. L.; Martins, Pedro M.; Lanceros-Mendez, S., Silk fibroin-magnetic hybrid composite electrospun fibers for tissue engineering applications. Composites Part B-Engineering, 141, 70-75, 2018
Abstract(s)This manuscript reports on the fabrication of silk fibroin (SF)-based magnetic electrospun fiber composites as scaffolds for tissue engineering applications. The magnetic responsiveness of the SF composite fibers was achieved by the inclusion of cobalt ferrite (CoFe2O4) or magnetite (Fe3O4) nanoparticles prior to processing the fibers via electrospinning. The influence of the processing parameters, including type and amount of nanoparticles in the composite, on the mean fiber size and size distribution was studied. Whereas the average diameter of pristine SF fibers was of 294±53nm, the inclusion of 5% of CoFe2O4 and Fe3O4 nanoparticles led to a slight increase in the fiber diameter. Nevertheless, the fiber diameter decreased with the higher nanoparticles loading. Regarding the physico-chemical properties of the fibrous mats, it was observed that the degree of crystallinity dropped from 67% of the pristine SF mats to 37% for the SF composites. On the other hand, the onset degradation temperature of the SF electrospun was not significantly altered by inclusion of ferrite nanoparticles. It is shown that the magnetization saturation increased with the nanoparticle filler content for both compositions (CoFe2O4/SF and Fe3O4/SF). Neither the SF pristine fibers nor the SF composites were cytotoxic, indicating their suitability for tissue engineering applications.
TypeArticle
URIhttp://hdl.handle.net/1822/50465
DOI10.1016/j.compositesb.2017.12.046
ISSN13598368
Publisher versionhttp://www.journals.elsevier.com/composites-part-b-engineering
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_47362_1.pdf
  Restricted access
770,52 kBAdobe PDFView/Open    Request a copy!

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID