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TitleProduction of dicarboxylic acid platform chemicals using yeasts: focus on succinic acid
Author(s)Pais, Célia
Franco-Duarte, Ricardo
Sampaio, Paula
Wildner, Jessica
Carolas, Ana
Figueira, Diogo
Ferreira, Bruno Sommer
Keywords1,4-Butanediol (BDO)
Azelaic acid
Biobased chemicals
Citraconic acid
Crotonic acid
Dicarboxylic acids
Diethyl maleate
Downstream processing (DSP)
Fumaric acid
Glutaric acid
Glyoxylic acid
Itaconic acid
Maleic acid
Metabolic engineering
Polybutylene succinate (PBS)
Renewable raw materials
Succinic acid
Succinic anhydride
Tetrahydrofuran (THF)
Issue date2016
Abstract(s)The biotechnological production of biobased dicarboxylic acids has recently become a hot topic in industrial biotechnology, with many investments involved in the development, piloting, and validation at demonstration scale of diverse processes using renewable raw materials. This chapter will review the main markets and applications of commercially relevant dicarboxylic acids and will briefly present their current chemical and biotechnological production processes. The chapter will mainly focus on the particular case of succinic acid. The microbial platforms that have been proposed will be reviewed with emphasis on yeast strains. The basic requirements for setting up and scaling the bioprocess and the required purification strategy to obtain an economically feasible process yielding a product meeting the required specifications will be presented. Throughout the chapter, the specific challenges of using very low-cost raw materials such as agro-industrial residues will be highlighted.
TypeBook part
AccessOpen access
Appears in Collections:DBio - Livros e Capítulos de Livros/Books and Books Chapters

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