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TitleSmart drug delivery systems for cancer therapy
Author(s)Bárbara, Eduarda
Ozolina, Raza
Carvalho, Ana M.
Soares, Telma
Gonçalves, Hugo
Jana B. Nieder, Jana B.
Real Oliveira, M. Elisabete C.D.
Lúcio, M.
Issue date4-Jul-2017
Abstract(s)Ideal nanocarrier-based therapy, contains first a controlled mechanism for drug delivery, to minimize side effects in healthy tissues, and second has the ability to provide a controlled drug release to extend the therapeutic duration of the therapeutic treatment. Nanocarrier based chemotherapy is one of the few nanotechnology-based medical therapies that reached the clinics, already in 1995, when the commercial anti cancer drug delivery system DOXIL® was introduced in the market, but available systems are far from optimal selectivity and controlled release. Our work describes a combined spectroscopy and imaging study to evaluate the two aspects of a smart drug delivery system. In our study we used these DODAX:MO (1:2) formulations with a diameter of approx. 100 nm to study the biophysical characteristics when used for trafficking paclitaxel (PTX) and doxorubicin (DOX), both widely used chemotherapeutic anti-cancer drugs. Taking advantage of the of DOX intrinsic fluorescence also the cell uptake is studied for DODAB:MO (1:2) liposomal formulations.
TypePanel presentation
AccessOpen access
Appears in Collections:CDF - FAMO - Comunicações/Communications (with refereeing)

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