Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50294

TitleBioengineered cell culture systems of central nervous system injury and disease
Author(s)Teixeira, Fábio Gabriel Rodrigues
Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Marques, Fernanda
Sousa, João Carlos
Sousa, Nuno
Silva, Nuno A.
Silva, Rita Catarina Assunção Ribeiro
Lima, Rui Augusto Ribeiro
Salgado, A. J.
Issue date2016
PublisherElsevier
JournalDrug Discovery Today
Abstract(s)Cell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.
TypeArticle
URIhttp://hdl.handle.net/1822/50294
DOI10.1016/j.drudis.2016.04.020
ISSN1359-6446
e-ISSN1878-5832
Publisher versionhttps://www.journals.elsevier.com
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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