Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/50294

TítuloBioengineered cell culture systems of central nervous system injury and disease
Autor(es)Teixeira, Fábio Gabriel Rodrigues
Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Marques, Fernanda
Sousa, João Carlos
Sousa, Nuno
Silva, Nuno A.
Silva, Rita Catarina Assunção Ribeiro
Lima, Rui Augusto Ribeiro
Salgado, A. J.
Data2016
EditoraElsevier
RevistaDrug Discovery Today
Resumo(s)Cell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.
Tipoarticle
URIhttp://hdl.handle.net/1822/50294
DOI10.1016/j.drudis.2016.04.020
ISSN1359-6446
e-ISSN1878-5832
Versão da editorahttps://www.journals.elsevier.com
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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