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|Title:||Bioengineered cell culture systems of central nervous system injury and disease|
|Author(s):||Teixeira, Fábio Gabriel Rodrigues|
Vasconcelos, Natália L.
Gomes, Eduardo Domingos Correia
Sousa, João Carlos
Silva, Nuno A.
Silva, Rita Catarina Assunção Ribeiro
Lima, Rui Augusto Ribeiro
Salgado, A. J.
|Journal:||Drug Discovery Today|
|Abstract(s):||Cell culture systems, either 2D or explant based, have been pivotal to better understand the pathophysiology of several central nervous system (CNS) disorders. Recently, bioengineered cell culture systems have been proposed as an alternative to the traditional setups. These innovative systems often combine different cell populations in 3D environments that more closely recapitulate the different niches that exist within the developing or adult CNS. Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma.|
|Appears in Collections:||ICVS - Artigos em Revistas Internacionais com Referee|
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