Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50170

TitleYeast as a tool to explore cathepsin D function
Author(s)Pereira, H
Oliveira, C S F
Castro, L.
Preto, Ana
Chaves, S. R.
Côrte-Real, Manuela
Keywordscathepsin D
yeast model
apoptosis
yeast cathepsin D
cancer
Issue date11-Jul-2015
PublisherShared Science Publishers
JournalMicrobial Cell
Abstract(s)Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may constitute a therapeutic target. However, cathepsin D can have both anti- and pro-survival functions depending on its proteolytic activity, cellular context and stress stimulus. Therefore, a more detailed understanding of cathepsin D regulation and how to modulate its apoptotic functions is clearly needed. In this review, we provide an overview of the role of cathepsin D in physiological and pathological scenarios. We then focus on the opposing functions of cathepsin D in apoptosis, particularly relevant in cancer research. Emphasis is given to the role of the yeast protease Pep4p, the vacuolar counterpart of cathepsin D, in life and death. Finally, we discuss how insights from yeast cathepsin D and its role in regulated cell death can unveil novel functions of mammalian cathepsin D in apoptosis and cancer.
TypeArticle
URIhttp://hdl.handle.net/1822/50170
DOI10.15698/mic2015.07.212
ISSN2311-2638
e-ISSN2311-2638
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DBio - Artigos/Papers

Files in This Item:
File Description SizeFormat 
mic-02-225.pdf399,67 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID