Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/50165

TitleNovel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Author(s)Teixeira, Ricardo G.
Brás, Ana Rita
Côrte-Real, Leonor
Tatikonda, Rajendhraprasad
Sanches, Anabela
Robalo, M. Paula
Avecilla, Fernando
Moreira, Tiago Manuel Martins
Garcia, M. Helena
Haukka, Matti
Preto, Ana
Valente, Andreia
KeywordsApoptosis
Colorectal cancer
Ruthenium methylcyclopentadienyl
Selectivity
Issue date1-Jan-2018
PublisherElsevier
JournalEuropean Journal of Medicinal Chemistry
Abstract(s)Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
TypeArticle
URIhttp://hdl.handle.net/1822/50165
DOI10.1016/j.ejmech.2017.11.059
ISSN0223-5234
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DBio - Artigos/Papers

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