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TitleNovel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
Author(s)Teixeira, Ricardo G.
Brás, Ana Rita
Côrte-Real, Leonor
Tatikonda, Rajendhraprasad
Sanches, Anabela
Robalo, M. Paula
Avecilla, Fernando
Moreira, Tiago Manuel Martins
Garcia, M. Helena
Haukka, Matti
Preto, Ana
Valente, Andreia
Colorectal cancer
Ruthenium methylcyclopentadienyl
Issue date1-Jan-2018
JournalEuropean Journal of Medicinal Chemistry
Abstract(s)Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
AccessOpen access
Appears in Collections:DBio - Artigos/Papers

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