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TitleImpairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits
Author(s)Coimbra, Bárbara Guimarães Salazar
Cunha, Carina Isabel Soares
Borges, Sónia Maria de Sousa
Vasconcelos, Nivaldo António Portela de
Sousa, Nuno
Rodrigues, Ana João
Issue date24-Aug-2017
PublishereLife Sciences Publications, Ltd
CitationCoimbra, B., Soares-Cunha, C., Borges, S., Vasconcelos, N. A., Sousa, N., & Rodrigues, A. J. (2017). Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits. eLife, 6
Abstract(s)Ventral tegmentalt area (VTA) activity is critical for reward/reinforcement and is tightly modulated by the laterodorsal tegmentum (LDT). In utero exposure to glucocorticoids (iuGC) triggers prominent motivation deficits but nothing is known about the impact of this exposure in the LDT-VTA circuit. We show that iuGC-rats have long-lasting changes in cholinergic markers in the LDT, together with a decrease in LDT basal neuronal activity. Interestingly, upon LDT stimulation, iuGC animals present a decrease in the magnitude of excitation and an increase in VTA inhibition, as a result of a shift in the type of cells that respond to the stimulus. In agreement with LDT-VTA dysfunction, we show that iuGC animals present motivational deficits that are rescued by selective optogenetic activation of this pathway. Importantly, we also show that LDT-VTA optogenetic stimulation is reinforcing, and that iuGC animals are more susceptible to the reinforcing properties of LDT-VTA stimulation.
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Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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