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dc.contributor.authorAlves, Nuno Dinis Lopes Oliveirapor
dc.contributor.authorSilva-Correia, Joanapor
dc.contributor.authorPatrício, Patrícia Carvalhopor
dc.contributor.authorPinheiro, António Maria Restolho Mateuspor
dc.contributor.authorMachado-Santos, Ana R.por
dc.contributor.authorLoureiro-Campos, Eduardopor
dc.contributor.authorMorais, Mónicapor
dc.contributor.authorPeixoto, João Miguel Seiça Bessapor
dc.contributor.authorSousa, Nunopor
dc.contributor.authorPinto, Luísapor
dc.identifier.citationAlves, N. D., Correia, J. S., Patrício, P., Mateus-Pinheiro, A., Machado-Santos, A. R., Loureiro-Campos, E., ... & Pinto, L. (2017). Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression. Translational psychiatry, 7(3), e1058por
dc.description.abstractDepression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression. Through re-exposure to an unpredictable chronic mild stress protocol in rats, we observed the re-appearance of emotional and cognitive deficits. Furthermore, treatment with the antidepressants fluoxetine and imipramine was effective to promote sustained reversion of a depressive-like phenotype; however, their differential impact on adult hippocampal neuroplasticity triggered a distinct response to stress re-exposure: while imipramine re-established hippocampal neurogenesis and neuronal dendritic arborization contributing to resilience to recurrent depressive-like behavior, stress re-exposure in fluoxetine-treated animals resulted in an overproduction of adult-born neurons along with neuronal atrophy of granule neurons, accounting for an increased susceptibility to recurrent behavioral changes typical of depression. Strikingly, cell proliferation arrest compromised the behavior resilience induced by imipramine and buffered the susceptibility to recurrent behavioral changes promoted by fluoxetine. This study shows that previous exposure to a depressive-like episode impacts on the behavioral and neuroanatomical changes triggered by subsequent re-exposure to similar experimental conditions and reveals that the proper control of adult hippocampal neuroplasticity triggered by antidepressants is essential to counteract recurrent depressive-like episodes.por
dc.description.sponsorshipFCT (IF/01079/2014). This article has been developed under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). This work has been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the FCT, under the scope of the project POCI-01-0145-FEDER-007038por
dc.publisherNature Publishing Grouppor
dc.titleAdult hippocampal neuroplasticity triggers susceptibility to recurrent depressionpor
dc.subject.fosCiências Médicas::Medicina Básicapor
dc.subject.wosScience & Technologypor
sdum.journalTranslational Psychiatrypor
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