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TitleThe choroid plexus as a sex hormone target: Functional implications
Author(s)Santos, Cecília R.A.
Duarte, Ana Catarina
Quintela, Telma
Tomás, Joana
Albuquerque, Tânia
Marques, Fernanda
Palha, Joana Almeida
Gonçalves, Isabel
KeywordsChoroid plexus
Brain barriers
Immune surveillance
Cerebrospinal fluid
Chemical surveillance
Sex hormones
Circadian rhythm
Olfactory signalling
Taste signalling
Issue date8-Jan-2017
JournalFrontiers in Neuroendocrinology
CitationSantos, C. R., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., ... & Gonçalves, I. (2016). The choroid plexus as a sex hormone target: Functional implications. Frontiers in neuroendocrinology
Abstract(s)The choroid plexuses (CPs) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF). In recent years, novel functions have been attributed to this tissue such as in immune and chemical surveillance of the central nervous system, brain development, adult neurogenesis and circadian rhythm regulation. Sex hormones (SH) are widely recognized as modulators in several neurodegenerative diseases, and there is evidence that estrogens and androgens regulate several fundamental biological functions in the CPs. Therefore, SH are likely to affect the composition of the CSF impacting on brain homeostasis. This review will look at implications of the CPs' sex-related specificities.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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