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TitleSynthesis of N-tert-butyloxycarbonyl-3-nitro-l-tyrosine methyl ester
Author(s)Costa, Susana P. G.
Raposo, M. Manuela M.
Esteves, Cátia Isabel Canavezes
Ferreira, Rosa Cristina Moutinho
Keywordsα-Amino acid
IR spectroscopy
Liquid–liquid extraction
NMR spectroscopy
Nucleophilic substitution
Protecting group
Organic chemistry experiments
Laboratory classroom
Issue dateDec-2016
PublisherRoyal Society of Chemistry
CitationComprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 2016, Cap. 45, Experiment 3.1.14, p 198-201.
Abstract(s)The aim of this work is the synthesis of a protected amino acid derivative, namely, tyrosine, using simple experimental techniques and commercially available reagents. The protection will be accomplished by classical reactions in organic chemistry: preparation of an ester from a carboxylic acid by nucleophilic substitution (conversion of the carboxylic acid into an acid chloride) followed by alcoholysis; preparation of a carbamate from an amine by acylation with a carbonate ester.
TypeBook part
Publisher version
AccessRestricted access (Author)
Appears in Collections:CDQuim - Livros e Capítulos de Livros / Books and Book Chapters

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