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TitleCD4 T Follicular Helper Cells and HIV Infection: Friends or Enemies?
Author(s)Moukambi, Félicien
Rodrigues, Vasco
Fortier, Yasmina
Rabezanahary, Henintsoa
Borde, Chloé
Krust, Bernard
Andreani, Guadalupe
Silvestre, Ricardo Jorge Leal
Petrovas, Constantinos
Laforge, Mireille
Estaquier, Jérôme
B cell
Issue date20-Feb-2017
PublisherFrontiers Media
JournalFrontiers in Immunology
CitationMoukambi, F., Rodrigues, V., Fortier, Y., Rabezanahary, H., Borde, C., Krust, B., et. al. (2017). CD4 T follicular helper cells and HIV infection: friends or enemies?. Frontiers in immunology, 8.
Abstract(s)Follicular T helper (Tfh) cells, a subset of CD4 T lymphocytes, are essential for memory B cell activation, survival, and differentiation and assist B cells in the production of antigen-specific antibodies. Work performed in recent years pointed out the importance of Tfh cells in the context of HIV and SIV infections. The importance of tissue distribution of Tfh is also an important point since their frequency differs between peripheral blood and lymph nodes compared to the spleen, the primary organ for B cell activation, and differentiation. Our recent observations indicated an early and profound loss of splenic Tfh cells. The role of transcriptional activator and repressor factors that control Tfh differentiation is also discussed in the context of HIV/SIV infection. Because Tfh cells are important for B cell differentiation and antibody production, accelerating the Tfh responses early during HIV/SIV infection could be promising as novel immunotherapeutic approach or alternative vaccine strategies. However, because Tfh cells are infected during the HIV/SIV infection and represent a reservoir, this may interfere with HIV vaccine strategy. Thus, Tfh represent the good and bad guys during HIV infection.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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