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https://hdl.handle.net/1822/49052
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Campo DC | Valor | Idioma |
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dc.contributor.author | Vale, Nuno | por |
dc.contributor.author | Correia, Alexandra | por |
dc.contributor.author | Silva, Sara | por |
dc.contributor.author | Figueiredo, Patrícia | por |
dc.contributor.author | Mäkilä, , Ermei | por |
dc.contributor.author | Salonen, Jarno | por |
dc.contributor.author | Hirvonen, Jouni | por |
dc.contributor.author | Pedrosa, Jorge | por |
dc.contributor.author | Santos Hélder A. | por |
dc.contributor.author | Fraga, Alexandra | por |
dc.date.accessioned | 2018-01-05T16:52:18Z | - |
dc.date.available | 2018-01-05T16:52:18Z | - |
dc.date.issued | 2017-02-01 | - |
dc.identifier.citation | Vale, N., Correia, A., Silva, S., Figueiredo, P., Mäkilä, E., Salonen, J., ... & Fraga, A. (2017). Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters, 27(3), 403-405 | por |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://hdl.handle.net/1822/49052 | - |
dc.description.abstract | Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium tuberculosis. Recently, we reported that the loading of ETH into thermally carbonized-porous silicon (TCPSi) nanoparticles enhanced the solubility and permeability of ETH at different pH-values and also increased its metabolization process. Based on these results, we synthesized carboxylic acid functionalized thermally hydrocarbonized porous silicon nanoparticles (UnTHCPSi NPs) conjugated with ETH and its antimicrobial effect was evaluated against Mycobacterium tuberculosis strain H37Rv. The activity of the conjugate was increased when compared to free-ETH, which suggests that the nature of the synergy between the NPs and ETH is likely due to the weakening of the bacterial cell wall that improves conjugate-penetration. These ETH-conjugated NPs have great potential in reducing dosing frequency of ETH in the treatment of multidrug-resistant tuberculosis (MDR-TB). (C) 2016 Elsevier Ltd. All rights reserved. | por |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia (FCT, Portugal) and FEDER (European Union) for funding through UID/MULTI/04378/2013, project grant IF/00092/2014 and IF2014 position. Thanks are also due to “Comissão de Coordenação e Desenvolvimento Regional do Norte (CCDR-N)/NORTE2020/Portugal 2020” for funding through project DESignBIOtechHealth (ref. Norte-01-0145-FEDER-000024). H.A.S. acknowledges financial support from the Academy of Finland (decision nos. 252215 and 281300), the University of Helsinki Research Funds, the Biocentrum Helsinki, and the European Research Council under the European Union’s Seventh Framework Programme (FP/2007–2013, Grant No. 310892). The content is solely the responsibility of the authors and does not necessarily represent the official views of the FCT or CCDR-N | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147258/PT | por |
dc.rights | openAccess | por |
dc.subject | Ethionamide | por |
dc.subject | Porous silicon nanoparticles | por |
dc.subject | Mycobacterium tuberculosis | por |
dc.subject | Strain H37Rv | por |
dc.subject | MIC50 | por |
dc.title | Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0960894X16313397 | por |
oaire.citationStartPage | 403 | por |
oaire.citationEndPage | 405 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 27 | por |
dc.date.updated | 2017-12-19T15:00:24Z | - |
dc.identifier.doi | 10.1016/j.bmcl.2016.12.060 | por |
dc.identifier.pmid | 28057421 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Bioorganic & Medicinal Chemistry Letters | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
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untitled.pdf | 409,9 kB | Adobe PDF | Ver/Abrir |