Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/49003

TitleThe Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
Author(s)Kuil, Larissa de Melo
Lorenzi, Adriana Tarla
Stein, Maíra Degiovani
Resende, Júlio César Possati
Antoniazzi, Márcio
Longatto Filho, Adhemar
Scapulatempo-Neto, Cristovam
Fregnani, José Humberto Tavares Guerreiro
KeywordsSecondary prevention
Papillomavirus infections
Cervical neoplasms
Molecular diagnostic techniques
Self-collection
Issue date11-Nov-2017
PublisherKarger Publishers
JournalActa Cytologica
Citationde Melo Kuil, L., Lorenzi, A. T., Stein, M. D., Resende, J. C. P., Antoniazzi, M., Longatto-Filho, A., ... & Fregnani, J. H. T. G. (2017). The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia. Acta Cytologica
Abstract(s)Objective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing. Methods: We enrolled 204 women who were aged 18-64 years and had previously obtained abnormal cervical cytology test results; 83.8% of them agreed to participate. The sample was divided into two aliquots: one for the cytological study and one for the molecular analysis of high-risk HPV. Results: Fifty-eight percent of the participants preferred to utilize self-collection as an alternative screening method. However, we noticed that the HPV positivity rate was significantly lower in self-collected samples when compared to those obtained using the conventional collection method (p = 0.035). The cytology tests of the samples obtained via self-collection were sensitive and had a positive predictive value and an area under the curve (AUC) that were significantly lower than those of the Pap test. However, the specificity and negative predictive value of these tests were similar. When compared with the HPV test, the self-collected samples demonstrated lower accuracy in predicting high-grade cervical intraepithelial neoplasia or worse, with a significantly lower sensitivity, positive predictive value, and AUC than the cervical Pap test samples. Conclusion: Self-collection by vaginal lavage is simple and well accepted by women. Due to its limitations, however, self-collection by lavage should be utilized with caution.
TypeArticle
DescriptionThe Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
URIhttp://hdl.handle.net/1822/49003
DOI10.1159/000477331
ISSN0001-5547
e-ISSN1938-2650
Publisher versionhttps://www.karger.com/Article/Abstract/477331
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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