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TitleHost-derived biomarkers for risk assessment of invasive fungal diseases
Author(s)Cunha, Cristina Amorim
Gonçalves, Samuel M.
Carvalho, Agostinho Albérico Rodrigues
KeywordsInvasive fungal disease
Single nucleotide polymorphism (SNP)
Host biomarkers
Long pentraxin 3 (PTX3)
Antifungal immunity
Immunocompromised patients
Risk stratification
Personalized medicine
Issue date1-Jan-2017
PublisherHumana Press
JournalMethods in Molecular Biology
CitationCunha, C., Gonçalves, S. M., & Carvalho, A. (2017). Host-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases. Human Fungal Pathogen Identification: Methods and Protocols, 153-165
Abstract(s)Invasive fungal diseases are major complications associated with the treatment of hematologic malignancies. The integration of host-derived biomarkers into clinical processes to predict the risk and progression of fungal disease is a promising approach in immunocompromised patients. Recent insights into human antifungal immunity have highlighted the remarkable influence of host genetics in modulating susceptibility to infection. In this chapter, we describe protocols to examine human genetic variation and to assess its functional consequences using the pattern recognition receptor PTX3 as an example.
TypeBook part
DescriptionHost-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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