Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/48480

TitlePresence and severity of lower urinary tract symptoms are inversely correlated with the risk of prostate cancer on prostate biopsy
Author(s)Cicione, Antonio
Cormio, Luigi
Cantiello, Francesco
Palumbo, Italo M.
De Nunzio, Cosimo
Lima, Estêvão Augusto Rodrigues de
Ucciero, Giuseppe
Carrieri, Giuseppe
Damiano, Rocco
KeywordsLower urinary tract symptoms
Biopsy
Prostatic neoplasms
Issue dateOct-2017
PublisherEdizioni Minerva Medica
JournalMinerva Urologica e Nefrologica
CitationCicione A, Cormio L, Cantiello F, Palumbo IM, De Nunzio C, Lima E, et al. Presence and severity of lower urinary tract symptoms are inversely correlated with the risk of prostate cancer on prostate biopsy. Minerva Urol Nefrol 2017;69:486-92. DOI: 10.23736/S0393-2249.17.02737-0
Abstract(s)BACKGROUND: The assessment of lower urinary tract symptoms (LUTS) is common part of urological investigation. Furthermore, patients bother of prostate cancer (PCa) when they are affected of LUTS. This study was aimed to determine whether the presence and severity of LUTS, as assessed by the International Prostate Symptoms Score (IPSS), could help to identify patients at higher risk of prostate cancer (PCa) on prostate biopsy (PBx). In this effort, an initial PCa predictive model was calculated and IPSS was subsequently added. The diagnostic accuracy of both models was compared. METHODS: The analysis of prospectively collected data of patients scheduled for PBx at four academic hospitals between January 2012 and June 2015 was performed. Univariate and multivariate analysis assessed the correlation between the IPSS and the risk of being diagnosed with PCa; Receiver operator characteristic curve (ROC) analysis evaluated the predictive models including or not the IPSS. RESULTS: Of the 1366 enrolled patients, 706 (52%) were diagnosed with PCa. Patients with PCa had a significantly lower IPSS (10.6 +/- 7.4 vs. 12.7 +/- 8.1) than those with benign diagnosis. Multivariate logistic regression analysis showed that age, prostate-specific antigen (PSA), prostate volume and IPSS were the most significant predictors of PBx outcome, (OR 1.61, P=0.001; OR 1.20, P=0.001; OR 0.97, P=0.001; OR 0.74, P=0.004; respectively). ROC curve analysis showed that the addition of IPSS to the predictive model based on age, PSA, DRE and prostate volume significantly improved the model diagnostic accuracy (AUC: 0.776 vs. 0.652; P=0.001). CONCLUSIONS: Presence and severity of LUTS are inversely correlated with the risk of being diagnosed with PCa at PBx. Incorporating the IPSS into predictive models may reduce the risk of unnecessary PBxs.
Typearticle
URIhttp://hdl.handle.net/1822/48480
DOI10.23736/S0393-2249.17.02737-0
ISSN0393-2249
e-ISSN1827-1758
Publisher versionhttps://www.minervamedica.it/en/journals/minerva-urologica-nefrologica/article.php?cod=R19Y2017N05A0486
Peer-Reviewedyes
AccessopenAccess
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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