Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/48251

TitleGlycosaminoglycans from marine sources as therapeutic agents
Author(s)Valcarcel, J.
Novoa-Carballal, R.
Pérez-Martín, Ricardo I.
Reis, R. L.
Vázquez, José A.
KeywordsGlycosaminoglycans
Marine
Therapeutic
Regenerative medicine
Tissue engineering
Nervous system
Cancer
Antiviral
Anticoagulant
Inflammation
Issue dateJul-2017
PublisherElsevier
JournalBiotechnology Advances
CitationValcarcel J., Novoa-Carballal R., Pérez-Martín R. I., Reis R. L., José V. A. Glycosaminoglycans from marine sources as therapeutic agents, Biotechnology Advances, Vol. 35, Issue 6, pp. 711-725, doi:10.1016/j.biotechadv.2017.07.008, 2017
Abstract(s)Glycosaminoglycans (GAGs) in marine animals are different to those of terrestrial organisms, mainly in terms of molecular weight and sulfation. The therapeutic properties of GAGs are related to their ability to interact with proteins, which is very much influenced by sulfation position and patterns. Since currently GAGs cannot be chemically synthesized, they are sourced from natural products, with high intra- but also inter-species variability, in terms of chain length, disaccharide composition and sulfation pattern. Consequently, sulfated GAGs are the most interesting molecules in the marine environment and constitute the focus of the present review. In particular, chondroitin sulfate (CS) appears as the most promising compound. CS-E chains [GlcA-GalNAc(4S,6S)] extracted from squid possess antiviral and anti-metastatic activities and seem to impart signalling properties and improve the mechanical performance of cartilage engineering constructs; Squid CS-E and octopus CS-K [GlcA(3S)-GalNAc(4S)], dermatan sulfate (DS) from sea squirts [-iK units, IdoA(3S)-GalNAc(4S)] and sea urchins [-iE units, IdoA-GalNAc(4S,6S)] and hybrids CS/DS from sharks (-B/iB [GlcA/IdoA(2S)-GalNAc(4S)], -D/iD [GlcA/IdoA(2S)-GalNAc(6S)] and –E/iE units [GlcA/IdoA-GalNAc(4S,6S)]) promote neurite outgrowth and could be valuable materials for nerve regeneration. Also displaying antiviral and anti-metastatic properties, a rare CS with fucosylated branches isolated from sea cucumbers is an anticoagulant and anti-inflammatory agent. In this same line, marine heparin extracted from shrimp and sea squirt has proven anti-inflammatory properties, with the added advantage of decreased risk of bleeding because of its low anticoagulant activity.
TypeArticle
URIhttp://hdl.handle.net/1822/48251
DOI10.1016/j.biotechadv.2017.07.008
ISSN0734-9750
e-ISSN1873-1899
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
19201-Glycosaminoglycans from marine sources as therapeutic agents.pdf
  Restricted access
772,75 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID