Please use this identifier to cite or link to this item:

TitleCell-laden composite suture threads for repairing damaged tendons
Author(s)Costa-Almeida, R.
Domingues, R. M. A.
Fallahi, A.
Avci, H.
Yazdi, I. K.
Akbari, M.
Reis, R. L.
Tamayol, A.
Gomes, Manuela E.
Khademhosseini, A.
Cell-laden fibers
Composite sutures
Tendon Tissue Engineering
tissue regeneration
cell-laden fibres
Issue date2018
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationCosta-Almeida R., Domingues R. M. A., Fallahi A., Avci H., Yazdi I. K., Akbari M., Reis R. L., Tamayol A., Gomes M. E., Khademhosseini A. Cell-laden composite suture threads for repairing damaged tendons, Journal Of Tissue Engineering And Regenerative Medicine, doi:10.1002/term.2605, 2017
Abstract(s)Tendons have limited regenerative capacity due to their low cellularity and hypovascular nature, which results in poor clinical outcomes of presently used therapies. As tendon injuries are often observed in active adults, it poses an increasing socio-economic burden on healthcare systems. Currently, suture threads are used during surgical repair to anchor the tissue graft or to connect injured ends. Here, we created composite suture threads coated with a layer of cell-laden hydrogel that can be used for bridging the injured tissue aiming at tendon regeneration. In addition, the fibers can be used to engineer 3D constructs through textile processes mimicking the architecture and mechanical properties of soft tissues, including tendons and ligaments. Encapsulated human tendon-derived cells migrated within the hydrogel and aligned at the surface of the core thread. An up-regulation of tendon-related genes (scleraxis and tenascin C) and genes involved in matrix remodeling (MMP1, MMP2) was observed. Cells were able to produce a collagen-rich matrix, remodeling their microenvironment, which is structurally comparable to native tendon tissue.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
19226-Costa-Almeida et al 2017_JTERM_AliK.pdf
  Restricted access
828,77 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID