Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/48154

TitleCell-laden composite suture threads for repairing damaged tendons
Author(s)Costa-Almeida, R.
Domingues, R. M. A.
Fallahi, A.
Avci, H.
Yazdi, I. K.
Akbari, M.
Reis, R. L.
Tamayol, A.
Gomes, Manuela E.
Khademhosseini, A.
KeywordsBiotextiles
Braiding
Cell-laden fibers
Composite sutures
Tendon Tissue Engineering
tissue regeneration
cell-laden fibres
Issue date2018
PublisherWiley
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationCosta-Almeida R., Domingues R. M. A., Fallahi A., Avci H., Yazdi I. K., Akbari M., Reis R. L., Tamayol A., Gomes M. E., Khademhosseini A. Cell-laden composite suture threads for repairing damaged tendons, Journal Of Tissue Engineering And Regenerative Medicine, doi:10.1002/term.2605, 2017
Abstract(s)Tendons have limited regenerative capacity due to their low cellularity and hypovascular nature, which results in poor clinical outcomes of presently used therapies. As tendon injuries are often observed in active adults, it poses an increasing socio-economic burden on healthcare systems. Currently, suture threads are used during surgical repair to anchor the tissue graft or to connect injured ends. Here, we created composite suture threads coated with a layer of cell-laden hydrogel that can be used for bridging the injured tissue aiming at tendon regeneration. In addition, the fibers can be used to engineer 3D constructs through textile processes mimicking the architecture and mechanical properties of soft tissues, including tendons and ligaments. Encapsulated human tendon-derived cells migrated within the hydrogel and aligned at the surface of the core thread. An up-regulation of tendon-related genes (scleraxis and tenascin C) and genes involved in matrix remodeling (MMP1, MMP2) was observed. Cells were able to produce a collagen-rich matrix, remodeling their microenvironment, which is structurally comparable to native tendon tissue.
TypeArticle
URIhttp://hdl.handle.net/1822/48154
DOI10.1002/term.2605
ISSN1932-7005
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/term.2605/full
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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