Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/48152

TitleEngineered tubular structures based on chitosan for tissue engineering applications
Author(s)Silva, Joana M.
Rodrigues, Luísa Cidália Guimarães
Silva, Simone Santos
Reis, R. L.
Duarte, Ana Rita C.
KeywordsBiofunctionality
Biomaterials
Biomimetic
Chitosan
Tissue engineering
Issue date2018
PublisherSAGE Publications
JournalJournal of Biomaterials Applications
CitationSilva J. M., Rodrigues L.C., Silva S. S., Reis R. L., Duarte A. R. C. Engineered tubular structures based on chitosan for tissue engineering applications, Journal of Biomaterials Applications, pp. 1-12, doi:10.1177/0885328217744698, 2018.
Abstract(s)The development of versatile tubular structures is a subject of broad interest in tissue engineering applications. Herein, we demonstrate the production of tubular structures based on chitosan through a combination of dipping, freeze-drying and supercritical technology approaches. The combination of these techniques yields versatile tubes with a perfectly defined hollow imprint, which upon chemical cross-linking with genipin acquire enhanced mechanical properties (Young Modulus (E) and ultimate tensile stress (smax)), as well as improved stability in wet conditions. The biological performance reveals that cells remain attached, well-spread and viable on the surface of cross-linked tubes. As so, is envisioned that our methodology opens up new avenues on tissue engineering approaches, where the design of tubular structures with tuned length, diameter and elasticity is required.
TypeArticle
URIhttp://hdl.handle.net/1822/48152
DOI10.1177/0885328217744698
ISSN0885-3282
e-ISSN1530-8022
Publisher versionhttp://journals.sagepub.com/eprint/FZDEhJHScaHJwA35UIII/full
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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