Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/48152

TítuloEngineered tubular structures based on chitosan for tissue engineering applications
Autor(es)Silva, Joana M.
Rodrigues, Luísa Cidália Guimarães
Silva, Simone Santos
Reis, R. L.
Duarte, Ana Rita C.
Palavras-chaveBiofunctionality
Biomaterials
Biomimetic
Chitosan
Tissue engineering
Data2018
EditoraSAGE Publications
RevistaJournal of Biomaterials Applications
CitaçãoSilva J. M., Rodrigues L.C., Silva S. S., Reis R. L., Duarte A. R. C. Engineered tubular structures based on chitosan for tissue engineering applications, Journal of Biomaterials Applications, pp. 1-12, doi:10.1177/0885328217744698, 2018.
Resumo(s)The development of versatile tubular structures is a subject of broad interest in tissue engineering applications. Herein, we demonstrate the production of tubular structures based on chitosan through a combination of dipping, freeze-drying and supercritical technology approaches. The combination of these techniques yields versatile tubes with a perfectly defined hollow imprint, which upon chemical cross-linking with genipin acquire enhanced mechanical properties (Young Modulus (E) and ultimate tensile stress (smax)), as well as improved stability in wet conditions. The biological performance reveals that cells remain attached, well-spread and viable on the surface of cross-linked tubes. As so, is envisioned that our methodology opens up new avenues on tissue engineering approaches, where the design of tubular structures with tuned length, diameter and elasticity is required.
Tipoarticle
URIhttp://hdl.handle.net/1822/48152
DOI10.1177/0885328217744698
ISSN0885-3282
e-ISSN1530-8022
Versão da editorahttp://journals.sagepub.com/eprint/FZDEhJHScaHJwA35UIII/full
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals


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