Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/48146

TitleUpdate on therapeutic approaches for rheumatoid arthritis
Author(s)Nogueira, Eugenia
Gomes, Andreia
Preto, Ana
Cavaco-Paulo, Artur
KeywordsAnimal models
DMARDs
Immunopathogenesis
Rheumatoid arthritis
Therapy
Issue date1-Jan-2016
PublisherBentham Science Publishers Ltd.
JournalCurrent Medicinal Chemistry
Abstract(s)Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that consumes considerable personal, social and economic costs. It consists of a syndrome of pain, stiffness and symmetrical inflammation of the synovial membrane (synovitis) of freely moveable joints such as the knee (diarthrodial joints). Although the etiology of rheumatoid arthritis is unclear, the disease is characterized by inflammation of the synovial lining of diarthrodial joints, high synovial proliferation and an influx of inflammatory cells, macrophages and lymphocytes through angiogenic blood vessels. Disease-modifying antirheumatic drugs slow disease progression and can induce disease remission in some patients. Methotrexate is the first line therapy, but if patients become intolerant to this drug, biologic agents should be used. The development of biological substances for the treatment of rheumatic conditions has been accompanied by ongoing health economic discussions regarding the implementation of these highly effective, but accordingly, highly priced drugs are the standard treatment guidelines of rheumatic diseases. In this way, more efficient strategies have to be identified. Despite numerous reviews in rheumatoid arthritis in the last years, this area is in constant development and updates are an urgent need to incorporate new advances in rheumatoid arthritis research. This review highlights the immunopathogenesis rationale for the current therapeutic strategies in rheumatoid arthritis.
TypeArticle
URIhttp://hdl.handle.net/1822/48146
DOI10.2174/092986732366616031612506
ISSN0929-8673
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
DBio - Artigos/Papers

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