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TitleChitosan-coated BSA nanoparticles for oral delivery
Author(s)Cunha, Joana Marques da
Lima, Rui
Sousa, Helena Isabel Teixeira de
Cavaco-Paulo, Artur
Issue date13-Mar-2016
PublisherAmerican Chemical Society
JournalAbstracts of Papers of the American Chemical Society
CitationCunha, J.; Lima, Rui; Sousa, H.; Cavaco-Paulo, Artur, Chitosan-coated BSA nanoparticles for oral delivery. 251st American Chemical Society National Meeting & Exposition - Computers in Chemistry. No. 563, San Diego, USA, March 13-17, 2016.
Abstract(s)Despite years of research, chronic pathologies, like cancer and chronic inflammatory diseases, are still in need of therapeutic approaches that allow easy administration, high compliance of the patient to the treatment and few or minor side effects. Engineered medicines, like surface-decorated nanoformulations, have the potential to accomplish all these important goals. However, oral administration of these formulations is a challenge due to the need to overcome the gastric harsh environment and be absorbed in the intestinal tract, reaching the blood flow as a whole functionalized particle. We developed BSA nanospheres coated with chitosan and/or poloxamer 407 as mucoadhesive and mucopenetrant polymers. The formulations showed to be non-toxic to Caco-2 cells in the tested concentrations. Stability assays in simulated digestive fluids showed differential profiles in terms of the size of the spheres coated with only one or with the two polymers and also in the amount of BSA that is released to the fluids, as measurement of spheres degradation. Preliminary results of ex vivo experiments with pig intestine showed the permeation of some material, however further improvements are being implemented in the analytic protocols. The overall results point to need of using both chitosan and poloxamer 407 as coating for BSA nanospheres to be orally administered and reach the target tissues.
Description251st American Chemical Society National Meeting & Exposition - Computers in Chemistry
Publisher version
AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

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