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TitleOil-based cyclo-oligosaccharide nanodevices for drug encapsulation
Author(s)Jennifer Noro
Loureiro, Ana Isabel Sá
Gonçalves, Filipa D.
Azóia, Nuno G.
Jung, Seunho
Silva, Carla
Cavaco-Paulo, Artur
palmitoyl chloride
Issue dateNov-2017
JournalColloids and Surfaces B: Biointerfaces
CitationJennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017
Abstract(s)New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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