Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/47468

TitleLiposomal formulations for specific drug delivery
Author(s)Nogueira, Eugénia Sofia Costa
Preto, Ana
Cavaco-Paulo, Artur
Issue date20-Nov-2013
CitationNogueira, E.; Preto, Ana; Cavaco-Paulo, Artur, Liposomal formulations for specific drug delivery. NANOFOL NanoDiaRA Conference in the 7th Framework Programme: Nanoparticles for Early Diagnostics of Inflammatory Diseases | New approaches in the field of soft and hard nanoparticles. Lisboa, Portugal, 2021 of November, 27, 2013.
Abstract(s)Liposomes have received considerable scrutiny as possible vehicles for drug delivery due to properties such as sustained release, increased drug stability, ability to overcome drug resistance and targeting of specific tissues. In this study, we have produced several liposomal formulations prepared by thin film hydration method. The different formulations were extensively characterized and preliminary tests were performed to evaluate their potential as specific drug delivery systems. The liposomes present very small values of size and polydispersity index, as well as lower cytotoxicity, which are compatible with intended in vivo applications. The incorporation of imaging and targeting agents in the liposomes was performed, what improved selectivity to the system, being the liposomes specifically internalized in target cells. The encapsulation of drugs was also performed and their effect analyzed in the target cells. In summary, the liposomal formulations obtained exhibit suitable characteristics to be used in vivo as specific drug delivery systems.
TypeAbstract
DescriptionNANOFOL NanoDiaRA Conference in the 7th Framework Programme: Nanoparticles for Early Diagnostics of Inflammatory Diseases | New approaches in the field of soft and hard nanoparticles
URIhttp://hdl.handle.net/1822/47468
Publisher versionhttps://www.nanodiara.eu/project-specific-events/conference-and-8th-scientific-meeting/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

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