Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/47044

TitleReappraising striatal D1- and D2-neurons in reward and aversion
Author(s)Cunha, Carina Isabel Soares
Coimbra, Bárbara Guimarães Salazar
Sousa, Nuno
Rodrigues, Ana João
KeywordsDopamine
Reward
Reinforcement
Aversion
Nucleus accumbens
Dorsal striatum
D1 dopamine receptor
D2 dopamine receptor
Mesolimbic
Nigrostriatal
Medium spiny neurons
Issue date2016
PublisherElsevier
JournalNeuroscience and Biobehavioral Reviews
Abstract(s)The striatum has been involved in complex behaviors such as motor control, learning, decision-making, reward and aversion. The striatum is mainly composed of medium spiny neurons (MSNs), typically divided into those expressing dopamine receptor D1, forming the so-called direct pathway, and those expressing D2 receptor (indirect pathway). For decades it has been proposed that these two populations exhibit opposing control over motor output, and recently, the same dichotomy has been proposed for valenced behaviors. Whereas D1-MSNs mediate reinforcement and reward, D2-MSNs have been associated with punishment and aversion. In this review we will discuss pharmacological, genetic and optogenetic studies that indicate that there is still controversy to what concerns the role of striatal D1- and D2-MSNs in this type of behaviors, highlighting the need to reconsider the early view that they mediate solely opposing aspects of valenced behaviour.
TypeArticle
URIhttp://hdl.handle.net/1822/47044
DOI10.1016/j.neubiorev.2016.05.021
ISSN0149-7634
e-ISSN1873-7528
Publisher versionhttps://www.journals.elsevier.com
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
soares-cunha et al. neuroscience and biobehavioral reviews 2016.pdf2,2 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID