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TitleNanoparticles for bone tissue engineering
Author(s)Vieira, Sílvia
Vial, Stephanie
Reis, R. L.
Oliveira, J. M.
KeywordsBone Tissue Engineering
Drug and Gene Delivery
Issue dateApr-2017
PublisherAmerican Institute of Chemical Engineers
JournalBiotechnology Progress
CitationVieira S., Vial S., Reis R. L., Oliveira J. M. Nanoparticles for Bone Tissue Engineering., Biotechnology Progress, doi:10.1002/btpr.2469, 2017
Abstract(s)Tissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone. Therefore, nanoengineered systems are now able to more closely mimic the structures observed in naturally occurring systems, and it is also possible to combine several approaches - such as drug delivery and cell labeling - within a single system. This review aims to cover the most recent developments on the use of different nanoparticles for bone TE, with emphasis on their application for scaffolds improvement; drug and gene delivery carriers, and labeling techniques.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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