Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/46798

TitleSusceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza glabra L.
Author(s)Martins, Natália
Costa-Oliveira, Sofia
Melo, Luís D. R.
Ferreira, Isabel C. F. R.
Azeredo, Joana
Henriques, Mariana
Silva, Sónia Carina
KeywordsGlycyrrhiza glabra L.
Methanol: water extract
Anti-Candida activity
Mechanism of action
Issue dateDec-2017
PublisherElsevier
JournalIndustrial Crops and Products
CitationMartins, Natália; Costa-Oliveira, Sofia; Melo, Luís D. R.; Ferreira, Isabel C. F. R.; Azeredo, Joana; Henriques, Mariana; Silva, Sónia Carina, Susceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza glabra L.. Industrial Crops and Products, 108, 480-484, 2017
Abstract(s)Medicinal plants and their botanical formulations have gained a pivotal attention among scientific researchers mainly due to its action as health promoters. Licorice (Glycyrrhiza glabra L.) constitutes a great example, with an increasingly evidenced antimicrobial potential. Opportunistic yeast infections constitute an alarming public health problem, highly exacerbated by the inefficacy of antifungal drugs and the increase of drug-resistant microorganisms, being Candida species one of the most common invaders. The present work aims to assess Candida glabrata and Candida albicans susceptibility to G. glabra methanol: water extract by using flow cytometry and transmission electron microscopy techniques. After 5 minutes, licorice extract (1.5 mg/mL) altered Candida membrane potential. Within an hour, it induced primary damages on Candida species cells, causing cell cytoplasm disorganization with high evidence of cell membrane invaginations, making cells turgid. Thus, based on the current findings, licorice extract seems to be a promising anti-Candida agent, without presenting any toxic potential at the effective concentrations used.
TypeArticle
URIhttp://hdl.handle.net/1822/46798
DOI10.1016/j.indcrop.2017.07.008
ISSN0926-6690
e-ISSN1872-633X
Publisher versionhttp://www.elsevier.com/locate/issn/09266690
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_46843_1.pdf965,96 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID