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https://hdl.handle.net/1822/46748
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Campo DC | Valor | Idioma |
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dc.contributor.author | Machado, Daniela | por |
dc.contributor.author | Gaspar, Carlos | por |
dc.contributor.author | Palmeira-de-Oliveira, Ana | por |
dc.contributor.author | Cavaleiro, Carlos | por |
dc.contributor.author | Salgueiro, Lígia | por |
dc.contributor.author | Martinez-de-Oliveira, José | por |
dc.contributor.author | Cerca, Nuno | por |
dc.date.accessioned | 2017-10-23T10:46:18Z | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | Machado, Daniela; Gaspar, Carlos; Palmeira-de-Oliveira, Ana; Cavaleiro, Carlos; Salgueiro, Lígia; Martinez-de-Oliveira, José; Cerca, Nuno, Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections. Future Microbiology, 12(5), 407-416, 2017 | por |
dc.identifier.issn | 1746-0913 | por |
dc.identifier.uri | https://hdl.handle.net/1822/46748 | - |
dc.description.abstract | Aim: To evaluate the antibacterial activity of Thymbra capitata essential oil and its main compound, carvacrol, against Gardnerella vaginalis grown planktonically and as biofilms, and its effect of vaginal lactobacilli. Materials & methods: Minimal inhibitory concentration, minimal lethal concentration determination and flow cytometry analysis were used to assess the antibacterial effect against planktonic cells. Antibiofilm activity was measured through quantification of biomass and visualization of biofilm structure by confocal laser scanning microscopy. Results: T. capitata essential oil and carvacrol exhibited a potent antibacterial activity against G. vaginalis cells. Antibiofilm activity was more evident with the essential oil than carvacrol. Furthermore, vaginal lactobacilli were significantly more tolerant to the essential oil. Conclusion: T. capitata essential oil stands up as a promising therapeutic agent against G. vaginalis biofilm-related infections. | por |
dc.description.sponsorship | The authors are grateful to Foundation for Science and Technology (FCT, Portugal) for D Machado grant (SFRH/ BD/87569/2012) and financial support (FCT Strategic Project of UID/BIO/04469/2013 unit). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. | por |
dc.language.iso | eng | por |
dc.publisher | Future Medicine | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F87569%2F2012/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | bacterial vaginosis | por |
dc.subject | biofilms | por |
dc.subject | carvacrol | por |
dc.subject | Gardnerella vaginalis | por |
dc.subject | lactobacilli | por |
dc.subject | Thymbra capitata essential oil | por |
dc.title | Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.futuremedicine.com/loi/fmb | por |
dc.comments | CEB46735 | por |
oaire.citationStartPage | 407 | por |
oaire.citationEndPage | 416 | por |
oaire.citationIssue | 5 | por |
oaire.citationConferencePlace | United Kingdom | - |
oaire.citationVolume | 12 | por |
dc.date.updated | 2017-08-03T11:08:45Z | - |
dc.identifier.eissn | 1746-0921 | por |
dc.identifier.doi | 10.2217/fmb-2016-0184 | por |
dc.identifier.pmid | 28339292 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Future Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
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document_46735_1.pdf Acesso restrito! | 2,6 MB | Adobe PDF | Ver/Abrir |