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TitleThymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections
Author(s)Machado, Daniela
Gaspar, Carlos
Palmeira-de-Oliveira, Ana
Cavaleiro, Carlos
Salgueiro, Lígia
Martinez-de-Oliveira, José
Cerca, Nuno
Keywordsbacterial vaginosis
Gardnerella vaginalis
Thymbra capitata essential oil
Issue dateApr-2017
PublisherFuture Medicine
JournalFuture Microbiology
CitationMachado, Daniela; Gaspar, Carlos; Palmeira-de-Oliveira, Ana; Cavaleiro, Carlos; Salgueiro, Lígia; Martinez-de-Oliveira, José; Cerca, Nuno, Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections. Future Microbiology, 12(5), 407-416, 2017
Abstract(s)Aim: To evaluate the antibacterial activity of Thymbra capitata essential oil and its main compound, carvacrol, against Gardnerella vaginalis grown planktonically and as biofilms, and its effect of vaginal lactobacilli. Materials & methods: Minimal inhibitory concentration, minimal lethal concentration determination and flow cytometry analysis were used to assess the antibacterial effect against planktonic cells. Antibiofilm activity was measured through quantification of biomass and visualization of biofilm structure by confocal laser scanning microscopy. Results: T. capitata essential oil and carvacrol exhibited a potent antibacterial activity against G. vaginalis cells. Antibiofilm activity was more evident with the essential oil than carvacrol. Furthermore, vaginal lactobacilli were significantly more tolerant to the essential oil. Conclusion: T. capitata essential oil stands up as a promising therapeutic agent against G. vaginalis biofilm-related infections.
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AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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