Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/46622

TitleFunctionalization of electrospun polymeric wound dressings with antimicrobial peptides
Author(s)Felgueiras, Helena Prado
Amorim, M. T. Pessoa de
KeywordsElectrospun wound dressings
Functionalization
Acute and chronic wounds
Antimicrobial peptides
Biomedical potential
Issue date1-Aug-2017
PublisherElsevier
JournalColloids and Surfaces B: Biointerfaces
Abstract(s)Wound dressings have evolved considerably since ancient times. Modern dressings are now important systems that combine the physical and biochemical properties of natural and synthetic polymers with active compounds that are beneficial to wound healing. Antimicrobial peptides (AMPs) are the most recent addition to these systems. These aim to control the microbial proliferation and colonization of pathogens and to modulate the host's immune response. In the last decade, electrospun wound dressings have been extensively studied and the electrospinning technique recognized as an efficient approach for the production of nanoscale fibrous mats. The control of the electrospinning processing parameters, the selection of the polymer and AMPs, and the definition of the most appropriate AMPs' functionalization method contribute to the successful treatment of acute and chronic wounds. Although the use of electrospinning in wound dressings' production has been previously reviewed, the increased development of AMPs and the establishment of functionalization methods for wound dressings over recent years has increased the need for such research. In the present review, we approach all these subjects and reveal the promising therapeutic potential of wound dressings functionalized with AMPs.
TypeArticle
URIhttp://hdl.handle.net/1822/46622
DOI10.1016/j.colsurfb.2017.05.001
ISSN0927-7765
e-ISSN1873-4367
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:DET/2C2T - Artigos em revistas internacionais com arbitragem científica

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