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TitlePhage therapy as an alternative or complementary strategy to prevent and control biofilm-related infections
Author(s)Pires, Diana P.
Melo, Luís D. R.
Boas, Diana Patrícia Andrade Vilas
Sillankorva, Sanna
Azeredo, Joana
Issue dateOct-2017
JournalCurrent Opinion in Microbiology
CitationPires, Diana P.; Melo, Luís D. R.; Vilas Boas, Diana; Sillankorva, Sanna; Azeredo, Joana, Phage therapy as an alternative or complementary strategy to prevent and control biofilm-related infections. Current Opinion in Microbiology, 39, 48-56, 2017
Abstract(s)The complex heterogeneous structure of biofilms confers to bacteria an important survival strategy. Biofilms are frequently involved in many chronic infections in consequence of their low susceptibility to antibiotics as well as resistance to host defences. The increasing need of novel and effective treatments to target these complex structures has led to a growing interest on bacteriophages (phages) as a strategy for biofilm control and prevention. Phages can be used alone, as a cocktail to broaden the spectra of activity, or in combination with other antimicrobials to improve their efficacy. Here, we summarize the studies involving the use of phages for the treatment or prevention of bacterial biofilms, highlighting the biofilm features that can be tackled with phages or combined therapy approaches.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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