Please use this identifier to cite or link to this item:

TitleProtein-based nanoformulations for α-Tocopherol encapsulation
Author(s)Ghaheh, Fatemeh Shahmoradi
Khoddami, Akbar
Alihosseini, Farzaneh
Gomes, Andreia
Ribeiro, Artur
Cavaco-Paulo, Artur
Silva, Carla Manuela Pereira Marinho
anti-oxidant activity
protein-based nanoparticles
skin treatment
Issue dateMay-2017
JournalEngineering in Life Sciences
CitationGhaheh, Fatemeh Shahmoradi; Khoddami, Akbar; Alihosseini, Farzaneh; Gomes, Andreia; Ribeiro, Artur; Cavaco-Paulo, Artur; Silva, Carla, Protein-based nanoformulations for α-Tocopherol encapsulation. Engineering in Life Sciences, 17(5), 523-527, 2017
Abstract(s)Nanoparticles of bovine serum albumin (BSA) and silk fibroin (SF) with entrapped α-tocopherol were produced via ultrasonic emulsification. Populations with particle size of 200300 nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of α-tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.+ ability resulting from the synergistic effect between proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA:VO and BSA:SF:VO as biodegradable and non-toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_46244_1.pdf624,29 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID