Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/46389

TitleProtein-based nanoformulations for α-Tocopherol encapsulation
Author(s)Ghaheh, Fatemeh Shahmoradi
Khoddami, Akbar
Alihosseini, Farzaneh
Gomes, Andreia
Ribeiro, Artur
Cavaco-Paulo, Artur
Silva, Carla Manuela Pereira Marinho
Keywordsα-tocopherol
anti-oxidant activity
protein-based nanoparticles
skin treatment
ultrasounds
Issue dateMay-2017
PublisherWiley-Blackwell
JournalEngineering in Life Sciences
CitationGhaheh, Fatemeh Shahmoradi; Khoddami, Akbar; Alihosseini, Farzaneh; Gomes, Andreia; Ribeiro, Artur; Cavaco-Paulo, Artur; Silva, Carla, Protein-based nanoformulations for α-Tocopherol encapsulation. Engineering in Life Sciences, 17(5), 523-527, 2017
Abstract(s)Nanoparticles of bovine serum albumin (BSA) and silk fibroin (SF) with entrapped α-tocopherol were produced via ultrasonic emulsification. Populations with particle size of 200300 nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of α-tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.+ ability resulting from the synergistic effect between proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA:VO and BSA:SF:VO as biodegradable and non-toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin.
TypeArticle
URIhttp://hdl.handle.net/1822/46389
DOI10.1002/elsc.201600188
ISSN1618-0240
e-ISSN1618-2863
Publisher versionhttp://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1618-2863
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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