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TitleSolid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
Author(s)Rodrigues, Ana Rita Oliveira
Mendes, Pedro M. F.
Silva, Pedro M. L.
Machado, Vera Alexandra Pereira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
KeywordsMagnetic nanoparticles
Drug delivery
New antitumor compounds
Iron oxide nanoparticles
Aqueous magnetoliposomes
Solid magnetoliposomes
Antitumor drug
Dual cancer therapy
Issue date2017
JournalColloids and Surfaces B: Biointerfaces
CitationA.R.O. Rodrigues et. al., Colloids and Surfaces B: Biointerfaces 158 (2017) 460-468.
Abstract(s)Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
Publisher version
AccessEmbargoed access (2 Years)
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)
CDQuim - Artigos (Papers)

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Supplementary Material_Magnetite_Coll_SurfB.pdfInformação Suplementar369,62 kBAdobe PDFView/Open

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