Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/46278

TítuloSolid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer
Autor(es)Rodrigues, Ana Rita Oliveira
Mendes, Pedro M. F.
Silva, Pedro M. L.
Machado, Vera Alexandra Pereira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
Palavras-chaveMagnetic nanoparticles
Drug delivery
Magnetoliposomes
New antitumor compounds
Data2017
EditoraElsevier
RevistaColloids and Surfaces B: Biointerfaces
CitaçãoA.R.O. Rodrigues et. al., Colloids and Surfaces B: Biointerfaces 158 (2017) 460-468.
Resumo(s)Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
Tipoarticle
URIhttp://hdl.handle.net/1822/46278
DOI10.1016/j.colsurfb.2017.07.015
ISSN0927-7765
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0927776517304277
Arbitragem científicayes
AcessoembargoedAccess (2 Years)
Aparece nas coleções:CDQuim - Artigos (Papers)
CDF - FAMO - Artigos/Papers (with refereeing)

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PJGCoutinho_etal_2017_magnetoliposomes_ColSurfB_revised.pdfDocumento principal1,15 MBAdobe PDFVer/Abrir  Solicitar cópia ao autor!
Supplementary Material_Magnetite_Coll_SurfB.pdfInformação Suplementar369,62 kBAdobe PDFVer/Abrir  Solicitar cópia ao autor!

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