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|Title:||Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer|
|Author(s):||Rodrigues, Ana Rita Oliveira|
Mendes, Pedro M. F.
Silva, Pedro M. L.
Machado, Vera Alexandra Pereira
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
New antitumor compounds
Iron oxide nanoparticles
Dual cancer therapy
|Journal:||Colloids and Surfaces B: Biointerfaces|
|Citation:||A.R.O. Rodrigues et. al., Colloids and Surfaces B: Biointerfaces 158 (2017) 460-468.|
|Abstract(s):||Iron oxide nanoparticles, with diameters around 12 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7 Oe and a blocking temperature of 118 K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150 nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.|
|Access:||Embargoed access (2 Years)|
|Appears in Collections:||CDF - FAMO - Artigos/Papers (with refereeing)|
CDQuim - Artigos (Papers)
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|Documento principal||1,15 MB||Adobe PDF||View/Open|
|Informação Suplementar||369,62 kB||Adobe PDF||View/Open|