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TitleSynthetic Protein Biotechnology approaches for the creation of antimicrobial biopolymers
Author(s)Costa, André Manuel Abreu
Machado, Raul
Ribeiro, Artur J.
Collins, Tony
Thiagarajan, V.
Neves-Petersen, M.T.
Rodríguez-Cabello, J.C.
Gomes, Andreia Castro
Casal, Margarida
Issue date2015
Abstract(s)[Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. In the present work we explored the ABP-CM4 peptide properties from Bombyx mori for the creation of biopolymers with broad antimicrobial activity. An antimicrobial recombinant protein-based polymer (rPBP) was designed by cloning the DNA sequence coding for ABP-CM4 in frame with the N-terminus of the elastin-like recombinamer consisting of 200 repetitions of the pentamer VPAVG, here named A200. [...]
AccessOpen access
Appears in Collections:DBio - Comunicações/Communications in Congresses

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