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TitleSolid and aqueous magnetic liposomes as nanocarriers for a new potential drug active against breast cancer
Author(s)Rodrigues, Ana Rita Oliveira
Silva, Pedro M. L.
Almeida, B. G.
Araújo, João P.
Queiroz, Maria João R. P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
KeywordsMagnetic nanoparticles
Drug delivery
New antitumor compounds
Issue dateJan-2017
PublisherPhantoms Foundation
Abstract(s)In this work, iron oxide nanoparticles (NPs), with diameters around 12 nm, were synthesized by coprecipitation method. Both aqueous and solid magnetic liposomes containing magnetite NPs were obtained, with sizes below 140 nm. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being located mainly in the lipid membrane. A promising application of these magnetic liposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.
Publisher version
AccessOpen access
Appears in Collections:CDF - FAMO - Comunicações/Communications (with refereeing)
CDQuim - Comunicações e Proceedings

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