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TitleMagnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies
Author(s)Rodrigues, Ana Rita O.
Almeida, B. G.
Rodrigues, Juliana M.
Queiroz, Maria João R. P.
Calhelha, R. C.
Ferreira, Isabel C. F. R.
Pires, A.
Pereira, A. M.
Araújo, João P.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
KeywordsMagnetic nanoparticles
Drug delivery
New antitumor drugs
Issue dateMar-2017
PublisherRoyal Society of Chemistry
JournalRSC Advances
CitationRSC Adv., 2017, 7, 15352
Abstract(s)Magnetoliposomes containing superparamagnetic manganese ferrite nanoparticles were tested as nanocarriers for two new promising antitumor drugs, a N-(3-methoxyphenyl)thieno[3,2-b]pyridin-7-amine (1) and a N-(2-methoxy-phenyl)thieno[3,2-b]pyridin-7-amine (2). The fluorescence emission of both compounds was studied in different polar and non-polar media, evidencing a strong intramolecular charge transfer character of the excited state of both compounds. These in vitro potent antitumor thienopyridine derivatives were successfully incorporated in both aqueous and solid magnetoliposomes, with encapsulation efficiencies higher than 75%. The magnetic properties of magnetoliposomes containing manganese ferrite nanoparticles were measured for the first time, proving a superparamagnetic behaviour. Growth inhibition assays on several human tumor cell lines showed very low GI50 values for drug-loaded aqueous magnetoliposomes, comparing in most cell lines with the ones previously obtained using the neat compounds. These results are important for future drug delivery applications using magnetoliposomes in oncology, through a dual therapeutic approach (simultaneous chemotherapy and magnetic hyperthermia).
Publisher version
AccessOpen access
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)
CDQuim - Artigos (Papers)

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