Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/45412

TítuloIn vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing
AutorSantos, L.
Silva, M.
Gonçalves, Ana I.
Pesqueira, T.
Rodrigues, Márcia T.
Gomes, Manuela E.
Palavras-chaveFibrous adhesions
Magnetic biomaterials
Tendon healing/repair
DataAbr-2016
EditoraFuture Medicine
CitaçãoSantos L., Silva M., Gonçalves A. I., Pesqueira T., Rodrigues M. T., Gomes M. E. In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing, Nanomedicine, Issue Revolutionising Healthcare, pp. 1, doi:10.2217/nnm-2015-0014, 2016
ResumoAim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.
Tipoarticle
URIhttp://hdl.handle.net/1822/45412
DOI10.2217/nnm-2015-0014
ISSN1743-5889
Versão da editorahttp://www.futuremedicine.com/doi/abs/10.2217/nnm-2015-0014
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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