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TitleIn vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing
Author(s)Santos, L.
Silva, M.
Gonçalves, Ana I.
Pesqueira, T.
Rodrigues, Márcia T.
Gomes, Manuela E.
KeywordsFibrous adhesions
Magnetic biomaterials
Tendon healing/repair
electromagnetic fields
magnetic responsive biomaterials
regenerative medicine
Issue dateApr-2016
PublisherFuture Medicine
CitationSantos L., Silva M., Gonçalves A. I., Pesqueira T., Rodrigues M. T., Gomes M. E. In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing, Nanomedicine, Issue Revolutionising Healthcare, pp. 1, doi:10.2217/nnm-2015-0014, 2016
Abstract(s)Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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