Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/45370
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Ríos-Tamayo, Rafael | por |
dc.contributor.author | Lupiañez, Carmen Belén | por |
dc.contributor.author | Campa, Daniele | por |
dc.contributor.author | Hielscher, Thomas | por |
dc.contributor.author | Weinhold, Niels | por |
dc.contributor.author | Martínez-López, Joaquin | por |
dc.contributor.author | Jerez, Andrés | por |
dc.contributor.author | Landi, Stefano | por |
dc.contributor.author | Reis, R. M. | por |
dc.contributor.author | Marques, Herlander | por |
dc.contributor.other | [et. al.] | - |
dc.date.accessioned | 2017-04-19T10:30:10Z | - |
dc.date.available | 2017-04-19T10:30:10Z | - |
dc.date.issued | 2016-09 | - |
dc.date.submitted | 2016-04 | - |
dc.identifier.citation | Ríos-Tamayo, R., Lupiañez, C. B., Campa, D., Hielscher, T., Weinhold, N., Martínez-López, J., et. al.(2016). A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: Results from the IMMEnSE consortium and meta-analysis. Oncotarget, 7(37), 59029 | por |
dc.identifier.issn | 1949-2553 | por |
dc.identifier.uri | https://hdl.handle.net/1822/45370 | - |
dc.description.abstract | Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec = 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8(rs13266634) SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1B(rs7501939) SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men. | por |
dc.description.sponsorship | This work was supported by grants from the FIBAO foundation (Granada, Spain), from the CRIS foundation against cancer, from the Cancer Network of Excellence (RD12/10 Red de Cáncer), from the Instituto de Salud Carlos III (Madrid, Spain; PI12/02688) and from the Dietmar Hopp Foundation and the German Ministry of Education and Science (BMBF: CLIOMMICS [01ZX1309]). | por |
dc.description.sponsorship | FIBAO foundation (Granada, Spain), from the CRIS foundation against cancer, from the Cancer Network of Excellence (RD12/10 Red de Cáncer), from the Instituto de Salud Carlos III (Madrid, Spain; PI12/02688) and from the Dietmar Hopp Foundation and the German Ministry of Education and Science (BMBF: CLIOMMICS [01ZX1309] | por |
dc.language.iso | eng | por |
dc.publisher | Impact Journals | por |
dc.rights | openAccess | por |
dc.subject | multiple myeloma | por |
dc.subject | diabetes | por |
dc.subject | genetic variants | por |
dc.subject | survival | por |
dc.title | A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=10665 | por |
sdum.publicationstatus | published | - |
oaire.citationStartPage | 59029 | por |
oaire.citationEndPage | 59048 | por |
oaire.citationIssue | 37 | por |
oaire.citationTitle | Oncotarget | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2017-03-01T11:16:13Z | - |
dc.identifier.eissn | 1949-2553 | por |
dc.identifier.doi | 10.18632/oncotarget.10665 | por |
dc.identifier.pmid | 27437873 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Oncotarget | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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10665-162204-7-pb.pdf | 5,78 MB | Adobe PDF | Ver/Abrir |