Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/45293

TítuloOsteogenesis evaluation of duck’s feet derived collagen/hydroxyapatite sponges immersed in dexamethasone
AutorKook, Y. J.
Lee, D. H.
Song, J. E.
Tripathy, N.
Jeon, Y. S.
Oliveira, J. M.
Reis, R. L.
Khang, G.
EditoraBioMed Central
CitaçãoKook Y. J., Lee D. H., Song J. E., Tripathy N., Jeon Y. S., Oliveira J. M., Reis R. L., Khang G. Osteogenesis evaluation of duck’s feet derived collagen/hydroxyapatite sponges immersed in dexamethasone, Biomaterials Research, Vol. 21, Issue 2, pp. 1-7, doi:10.1186/s40824-017-0088-4, 2017
ResumoBackground: The aim of this study was to investigate the osteogenesis effects of DC and DC/HAp sponge immersed in without and with dexamethasone. Methods: The experimental groups in this study were DC and DC/HAp sponge immersed in without dexamethasone (Dex(â )DC and Dex(â )-DC/HAp group) and with dexamethasone (Dex(+)-DC and Dex(+)-DC/HAp group). We characterized DC and DC/HAp sponge using compressive strength, scanning electron microscopy (SEM). Also, osteogenic differentiation of BMSCs on sponge (Dex(â )DC, Dex(â )-DC/HAp, Dex(+)-DC and Dex(+)-DC/HAp group) was assessed by SEM, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide (MTT) assay, alkaline phosphatase (ALP) activity assay and reverse transcription-PCR (RT-PCR). Results: In this study, we assessed osteogenic differentiation of BMSCs on Duckâ s feet-derived collagen (DC)/ HAp sponge immersed with dexamethasone Dex(+)-DC/HAp. These results showed that Dex(+)-DC/HAp group increased cell proliferation and osteogenic differentiation of BMSCs during 28 days. Conclusion: From these results, Dex(+)-DC/HAp can be envisioned as a potential biomaterial for bone regeneration applications.
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